Blar i forfatter "Kuzmiszyn, Adrina Kalasho"

Viser treff 1-4 av 4

    • Moderate but not severe hypothermia increases intracellular cyclic AMP through preserved production and reduced elimination 

      Kuzmiszyn, Adrina Kalasho; Selli, Anders Lund; Furuholmen, Markus; Smaglyukova, Natalia; Kondratiev, Timofei; Fuskevåg, Ole Martin; Sager, Georg; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-14)
      Rewarming from accidental hypothermia could be complicated by acute cardiac dysfunction but providing supportive pharmacotherapy at low core temperatures is challenging. Several pharmacological strategies aim to improve cardiovascular function by increasing cAMP in cardiomyocytes as well as cAMP and cGMP levels in vascular smooth muscle, but it is not clear what effects temperature has on cellular ...

    • Temperature-dependent effects of phosphodiesterase inhibitors for cardiovascular support in hypothermic patients - Effects on cellular elimination of cAMP and cGMP 

      Kuzmiszyn, Adrina Kalasho (Doctoral thesis; Doktorgradsavhandling, 2023-11-10)
      Hypothermia-induced cardiac dysfunction (HCD), commonly seen during rewarming, is one of the feared complications of accidental hypothermia. Animal studies with phosphodiesterase (PDE) inhibitors and sodium nitroprusside have demonstrated positive effects on reversing HCD. These medications act by indirectly increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine ...

    • Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate 

      Kuzmiszyn, Adrina Kalasho; Selli, Anders Lund; Smaglyukova, Natalia; Kondratiev, Timofei; Fuskevåg, Ole Martin; Lysaa, Roy A; Ravna, Aina Westrheim; Tveita, Torkjel; Sager, Georg; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      <p><b>Introduction:</b> Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiovascular dysfunction, which could lead to shock. Current guidelines do not recommend any pharmacological treatment at core temperatures below 30°C, due to lack of knowledge. However, previous in vivo studies have shown promising results when using phosphodiesterase 3 (PDE3) inhibitors, ...

    • Treatment of cardiovascular dysfunction with PDE5-inhibitors - temperature dependent effects on transport and metabolism of cAMP and cGMP 

      Selli, Anders Lund; Kuzmiszyn, Adrina Kalasho; Smaglyukova, Natalia; Kondratiev, Timofei V.; Fuskevåg, Ole Martin; Lyså, Roy Andre; Ravna, Aina Westrheim; Tveita, Torkjel; Sager, Georg; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
      <i>Introduction</i>: Cardiovascular dysfunction is a potentially lethal complication of hypothermia. Due to a knowledge gap, pharmacological interventions are not recommended at core temperatures below 30°C. Yet, further cooling is induced in surgical procedures and survival of accidental hypothermia is reported after rewarming from below 15°C, advocating a need for evidence-based treatment guidelines. ...